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超氧离子是人体内氧代谢的产物,它在体内过量积累会引起炎症、肿瘤等疾病,体内存在的超氧化物歧化酶(SOD)对O_2的歧化起催化作用。将O_2的浓度控制在一定水平。目前,SOD已试用于炎症、辐射病、癌症等的治疗。但是,由于SOD不稳定,且不易透过细胞膜,使其应用受到限制。近来研究表明,大环的过渡金属配合物可用作SOD的模拟物来研究酶的各种物理化学性质及歧化O_2~-的反应机理。大环配合物稳定性高,用作酶的模拟物有其独特的优点。
Superoxide ion is the product of oxygen metabolism in the human body. Excessive accumulation in the body can cause inflammation, tumor and other diseases. Superoxide dismutase (SOD) existing in the body acts as a catalyst for disproportionation of O 2. O 2 concentration will be controlled to a certain level. Currently, SOD has been tested for the treatment of inflammation, radiation sickness and cancer. However, the application of SOD is limited because of the unstable SOD and its impermeability to the cell membrane. Recent studies have shown that macrocyclic transition metal complexes can be used as mimics of SOD to study the various physicochemical properties of enzymes and the reaction mechanism of disproportionation of O 2 -. Macrocyclic complexes have high stability and their unique advantages as mimics for enzymes.