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大部分人类肿瘤是由基因组中的体细胞性改变所导致的癌基因激活或抑癌基因失活所引发的.本文总结了近年来肿瘤基因组中体细胞性改变的研究状况,我们主要关注人类基因组计划为肿瘤相关基因的鉴定所带来的机遇并讨论以全基因组分析为基础的研究进展.
Most human tumors are caused by the activation of oncogenes or the inactivation of tumor suppressor genes in somatic cells.This paper summarizes the research status of somatic changes in the tumor genome in recent years and we mainly focus on the human genome The program presents opportunities for the identification of tumor-associated genes and discusses advances in genome-based analysis.