【摘 要】
：
Iron deficiency anemia is one of the most common micronutrient deficient conditions around the globe with various consequences, including the weakened immune system. Quercetin is widely distributed bioflavonoid; it has been debated for its dual roles in i
【机 构】
：
Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and
论文部分内容阅读
Iron deficiency anemia is one of the most common micronutrient deficient conditions around the globe with various consequences, including the weakened immune system. Quercetin is widely distributed bioflavonoid; it has been debated for its dual roles in iron regulation. Quercetin-iron interaction in the body is a complex mechanism which has not been completely understood. The present study aimed to investigate the effect of quercetin on iron supplementation in iron deficiency anemia and on iNOS expression in splenic macrophages. The rat model of iron deficiency anemia was induced by feeding low iron diet to weanling rats for 20 days. The animals were then administered with ferrous sulfate, quercetin, and their combination for 30 days. Blood parameters, histopathological analysis, iron storage, CD68, iNOS and SLC40 expression in rat spleen were investigated. Our results showed that quercetin regulated iron absorption, despite SLC40 down-expression, indicating possible alternate route of iron transport, and that quercetin modulated iNOS production in splenic macrophages..
其他文献
Triptolide (TP) induces severe liver injury,but its hepatotoxicity mechanisms are still unclear.Inflammatory responses may be involved in the pathophysiology.Neutrophils are the first-line immune effectors for sterile and non-sterile inflammatory response
Polysaccharide from traditional Chinese herb,Saposhnikovia divaricata (Turcz.) Schischk.(SD) was extracted,fractionated and characterized in this work.Four fractions were prepared.Their molecular weight,monosaccharide compositions,linkage modes and struct
Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily of ligand-activated transcription factors. As a metabolic regulator, FXR plays key roles in bile acid and cholesterol metabolism and lipid and glucose homeostasis. Therefore, FXR i
Fibroblast-like synoviocytes (FLS) play a pivotal role in Rheumatoid arthritis (RA) pathogenesis through aggressive migration and invasion. Madecassoside (Madec), a triterpenoid saponin present in Centella asiatica herbs, has a potent anti-inflammatory ef
Macrophages play an important role in inflammation,and excessive and chronic activation of macrophages leads to systemic inflammatory diseases,such as atherosclerosis and rheumatoid arthritis.In this paper,we explored the anti-inflammatory effect of brous
The raw and processed roots of Plygonum multiflorum Thunb (PM) are used to treat different diseases in clinical practice. In order to clarify the influence of processing, a comparative study of chemical substance analysis was carried out. As the xenobioti
Five pairs of optically pure meroterpenoid enantiomers (1a/1b-5a/5b) and two known compounds (6 and 7) were isolated from Rhododendron fastigiatum.Compounds 1a/1b-5a/5b were resolved from naturally scalemic mixtures by chiral HPLC.Their structures were el
Thibetanosides E-H (1-4),four new steroidal constituents including three rare sulfonates (2-4),were isolated from the roots and rhizomes ofHelleborus thibetanus,together with nine known steroidal compounds (5-13).Their structures were elucidated by detail
The traditionally used oriental herbal medicine Moutan Cortex Radicis [MCR;Paeonia Suffruticosa Andrews (Paeoniaceae)] exerts anti-inflammatory,anti-spasmodic,and analgesic effects.In the present study,we investigated the therapeutic effects of differentl
Three new prenylated stilbenes,named as cajanusins A-C (1-3),and one new natural product cajanusin D (4),along with six known derivatives (5-10) were isolated from the leaves of Cajanus cajan.Their structures were fully elucidated by means of extensive sp