目的：观察早期颊癌组织内血管生成现象，研究新生血管超微结构特征及其与癌细胞浸润生长的相互关系，探讨肿瘤内血管异常对颊癌局部生物学行为的影响。方法：收集５例早期颊癌手术标本及临床资料，正常人颊部组织作对照，采取组织病理学方法及透射电镜技术进行研究。结果：早期颊癌细胞具有明显的侵袭特征，并诱发新生血管生成；伴随癌细胞的浸润，邻近毛细血管的内皮细胞代谢活跃出现增生表现；新形成的血管结构不完整，癌肿内多处可见结构缺损的毛细血管直接与癌细胞相邻。结论：早期颊癌内结构稳定、结构破坏和新形成血管同时存在，癌细胞局部浸润、漫延与其诱发血管生成相互促进，并表现出侵袭血管的趋势。新生血管很少成熟并为癌细胞的侵入提供了条件 OBJECTIVE: To observe the angiogenesis in the early cheek cancer, to study the ultrastructural characteristics of neovascularization and its relationship with the invasive growth of cancer cells, and to investigate the effect of intravascular vascular abnormalities on the local biological behavior of cheek cancer. METHODS: Five specimens and clinical data of early cheek cancer were collected. The buccal tissue of normal subjects was used as a control. Histopathological methods and transmission electron microscopy were used for the study. RESULTS: Early cheek cancer cells had obvious invasive characteristics and induced neovascularization. Along with the infiltration of cancer cells, endothelial cells in the adjacent capillaries were actively metabolized and proliferated. The newly formed vascular structures were incomplete, and cancers were seen in multiple locations. The structurally deficient capillaries are directly adjacent to the cancer cells. Conclusion: The structural stability, structural destruction and newly formed blood vessels of early cheek cancer are present at the same time. The local infiltration, spread of cancer cells and the angiogenesis induced by them mutually promote each other, and show the tendency of invasion of blood vessels. New blood vessels rarely mature and provide the conditions for the invasion of cancer cells