2/3肝叶切除18-24小时后喂以DEN,能启动形成较多的癌前变异病灶,除考虑细胞s期较易形成变异细胞外,尚应考虑肝叶切除诱发小叶周边较幼稚肝细胞增生时比小叶内分化成熟细胞受致癌物质的启动更易形成变异细胞。透明细胞是严重代谢障碍的现象,它们多趋向退行性变,所以不一定是癌前性质的细胞。 2/3 After hepatectomy for 18-24 hours, DEN can be fed to initiate the formation of more precancerous lesions. In addition to considering that cells are more likely to form variant cells in the s phase, hepatic lobectomy should be considered to induce hepatic hyperplasia around the leaflets. When the cells proliferate, they are more likely to form mutant cells than the initiation of carcinogens in the differentiated mature cells in the leaflets. Clear cells are a serious metabolic disorder, and they tend to be degenerative, so they are not necessarily precancerous cells.