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早期糖尿病肾病患者(尿微量白蛋白:20～200mg/L)60例随机分为常规治疗组(n=30)和氯吡格雷治疗组(n=30),氯吡格雷组在常规治疗组基础上加用氯吡格雷75mg每晚口服,持续1月,测定各组治疗前、后血液流变学指标及血糖、血脂、U-mAlb。结果氯吡格雷组的全血粘度、血浆比粘度、血浆纤维蛋白原浓度、血小板聚集率及尿微量白蛋白均显著低于常规治疗组(P<0.05),结论氯吡格雷对早期糖尿病肾病患者血液流变学有不同程度的改善并能有效降低尿微量白蛋白。
60 patients with early diabetic nephropathy (urinary albumin: 20 ~ 200mg / L) were randomly divided into routine treatment group (n = 30) and clopidogrel treatment group (n = 30) Add clopidogrel 75mg per night orally for 1 month, measured before and after treatment in each group hemorheological parameters and blood glucose, blood lipids, U-mAlb. Results The whole blood viscosity, plasma specific viscosity, plasma fibrinogen concentration, platelet aggregation rate and urinary microalbumin in clopidogrel group were significantly lower than those in the conventional treatment group (P <0.05). Conclusion Clopidogrel was effective in patients with early diabetic nephropathy Hemorheology has varying degrees of improvement and can effectively reduce urinary microalbumin.