新生儿脑损伤是我国目前导致新生儿死亡及小儿致残的主要疾病之一,已成为当今围产医学研究的重要课题。新生儿脑损伤的发病机制仍不清楚,也缺乏有效的治疗手段,故需从细胞水平研究新生儿脑损伤的发病机制和治疗方法。近几年的研究提示,缺氧缺血后神经元、胶质细胞、巨噬细胞等可通过产生过量的炎症因子对缺氧做出过激反应,从而造成对脑组织的进一步损伤。如白细胞介素(interleukin,IL)、肿瘤坏死因子-α(tumor necrosis Neonatal brain injury is one of the major diseases that cause neonatal death and pediatric disability in our country and has become an important issue in perinatal medical research. The pathogenesis of neonatal brain injury is still not clear, but also the lack of effective treatment, it is necessary to study the pathogenesis and treatment of neonatal brain injury at the cellular level. In recent years, research suggests that after hypoxic-ischemic neurons, glial cells, macrophages and other excessive inflammatory cytokines by over-reacting to hypoxia, resulting in further damage to brain tissue. Such as interleukin (IL), tumor necrosis factor-alpha