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麦角乙脲(lisenil,lisurid)是半合成麦角生物碱,化学结构和作用机制近似甲磺酸溴麦角环肽(par-lodel,PLD)。治疗肢端肥大症11例,男2例,女9例,年龄19～60岁。其中生长激素腺瘤8例,生长激素和催乳素腺瘤3例。使用麦角乙脲剂量0.44±0.01mg/d,治疗4.13±1.3月。其中有效7例,治疗期生长激素水平降低(P<0.05),恢复正常3例,催乳素水平降低(P<0.05);头痛减轻,舌和面部水肿减轻,劳动能力提高。无效4例,其中2例曾用 PLD 治疗有效。催乳素腺瘤48例,男9例,女39例,年龄18～84岁(20～40岁36例)。使用麦角乙脲0.46±0.03mg/d,治疗5.5±0.6月。有效34例(71%),催乳素降低50%,乳溢和头痛减轻或消失,月经周期恢复。4侧肿瘤缩小(治疗半年以上),治疗后怀孕2例。出现轻度副作用(眩晕、恶心、嗜睡)7例,随用药习惯逐渐消失。无效14例,其中11例曾用 PLD治疗有效。
Lisuride (lisurid) is a semisynthetic ergot alkaloid with similar chemical structure and mechanism of action as par-lodel (PLD). Acromegaly treatment of 11 cases, 2 males and 9 females, aged 19 to 60 years. Including growth hormone adenoma in 8 cases, growth hormone and prolactinoma in 3 cases. The dose of lisuride was used at 0.44 ± 0.01 mg / day for 4.13 ± 1.3 months. Among them, 7 cases were effective, and the levels of growth hormone were decreased (P <0.05), normalized in 3 cases and decreased in prolactin level (P <0.05). The headache was relieved, the tongue and facial edema were relieved, and the working ability was improved. 4 cases were ineffective, of which 2 cases had been treated with PLD. Prolactinoma in 48 cases, 9 males and 39 females, aged 18 to 84 years (20 to 40 years old in 36 cases). The use of lisuride 0.46 ± 0.03mg / d, treatment 5.5 ± 0.6 months. Effective in 34 cases (71%), prolactin reduced by 50%, milk overflow and headache to reduce or disappear, menstrual cycle recovery. 4 side tumor shrink (treatment more than six months), after treatment, 2 cases of pregnancy. 7 cases of mild side effects (dizziness, nausea, drowsiness) gradually disappeared with the medication habit. 14 cases were ineffective, of which 11 cases had been treated with PLD.