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以2,3-二甲基-4-氯-N-氧代吡啶(1)为起始原料,与3-甲氧基丙醇缩合反应得中间体2,中间体2再与醋酐反应得中间体3,经水解、氯化后得中间体4,中间体4与5缩合反应得硫醚6,最后经氧化得吡美拉唑(7),总收率16%。吡美拉唑结构通过1HNMR、MS方法进行了确认。
The intermediate 2 was synthesized from 2,3-dimethyl-4-chloro-N-oxopyridine (1) by condensation reaction with 3-methoxypropanol, then the intermediate 2 was reacted with acetic anhydride Intermediate 3, after hydrolysis, chlorination intermediate 4, the condensation reaction of intermediates 4 and 5 to give thioether 6, the final oxidation of pirameprazole (7), the total yield of 16%. The pirazepazole structure was confirmed by 1H NMR and MS methods.