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5-氟脲嘧啶(5-FU)广泛用于治疗恶性肿瘤后,有关其毒性作用已陆续有所报道,如胃肠道疾患、骨髓抑制、皮肤病变及神经毒性等。近来,临床发现某些病人每天用量750mg(总量4500mg)时,产生伴有缺血性ECG变化的心前区疼痛。兔子实验也证明输注15mg/kg的5-FU,在产生心室颤动后24小时内死亡,各种实验动物对5-FU心脏毒性的敏感性差异很大,其中豚鼠最敏感。本文作者进一步研究5-FU对豚鼠心脏的毒性。
5-fluorouracil (5-FU) is widely used in the treatment of malignant tumors, the toxic effects have been reported, such as gastrointestinal disorders, myelosuppression, skin lesions and neurotoxicity. Recently, it has been clinically found that some patients have a precordial pain associated with ischemic ECG changes when they are administered in an amount of 750 mg per day (a total of 4500 mg). Rabbit experiments also proved that infusion of 15mg / kg of 5-FU, died within 24 hours after the onset of ventricular fibrillation, the sensitivity of various experimental animals on 5-FU cardiotoxicity is very different, of which guinea pigs are the most sensitive. The authors further study the toxicity of 5-FU to guinea pig hearts.