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目的评估脂阿拉伯甘露糖─ＩｇＧ（ＬＡＭ－ＩｇＧ）和包膜蛋白─ＩｇＧ对活动性结核的诊断价值。方法两种抗原分别采用快速和常规酶朕免疫吸附法（ＥＬＩＳＡ）进行检测。选择１０８例活动性结核（其中９７例活动性肺结核、１１例肺外结核），６９例非结核肺部疾患（其中肺癌１６例，其它肺部疾患５３例）血清平行检测结核分支杆菌ＩｇＧ抗体。结果９７例活动性肺结核涂阳敏感性分别为７１．８％（２８／３９）和９２．３％（３６／３９），涂阴为６０．３％（３５／５８）和７７．６％（４５／５８）。６９例非结核肺部疾患组两法阳性分别为４例和１４例，假阳性率分别为５．８％（４／６９）和２０．３％（１４／６９）；特异性分别为９４．２％（６５／６９）和７９．７％（５５／６９）。结论提示快速ＥＬＩＳＡ血清ＬＡＭ－ＩｇＧ测定操作简便、快速、不需任何仪器设备且特异性较高，对活动性结核病有较高的临床辅助诊断价值。
Objective To evaluate the diagnostic value of lipoarabinomannan-IgG (IgA) and envelope protein-IgG in patients with active tuberculosis. Methods Both antigens were detected by rapid and routine enzyme-linked immunosorbent assay (ELISA). Mycobacterium tuberculosis IgG antibodies were detected in sera of 108 cases of active tuberculosis (97 active tuberculosis and 11 extrapulmonary tuberculosis) and 69 cases of non-tuberculosis pulmonary disease (16 cases of lung cancer and 53 cases of other lung diseases). Results The sensitivity of smear-positive in 97 cases of active pulmonary tuberculosis was 71.8% (28/39) and 92.3% (36/39) respectively, and the smear negative was 60.3% (35/58) and 77.6% 45/58). The positive rates of two methods in 69 cases of non-tuberculosis pulmonary disease group were 4 cases and 14 cases respectively, the false-positive rates were 5.8% (4/69) and 20.3% (14/69) respectively, and the specificity was 94%. 2% (65/69) and 79.7% (55/69). Conclusions Rapid ELISA serum LAM-IgG assay is simple, rapid, without any equipment and high specificity, and has a high clinical diagnostic value for active tuberculosis.