Role of nuclear receptor CAR in carbon tetrachloride-induced hepatotoxicity

来源 :世界胃肠病学杂志：英文版（电子版） | 被引量 : 0次 | 上传用户：ggooddII

【摘要】

：

AIM: To investigate the precise roles of CAR in CCl4-induced acute hepatotoxicity.METHODS: To prepare an acute liver injury model, CCl4 was intraperitoneally in

【作者】

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Yuichi Yamazaki Satoru Kakizak

【机构】

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DepartmentofMedicineandMolecularScience,PharmacogeneticsSection

【出处】

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世界胃肠病学杂志：英文版（电子版）

【发表日期】

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2005年38期

【关键词】

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核受体四氯化碳肝中毒病理机制 CAR Phenobarbital Cytochrome P450 CCl4 Drug-induced liver i

【基金项目】

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Grant-in Aid for Scientific Research，the Ministry of Education, Science, Sports and Culture of the Japanese Government

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AIM: To investigate the precise roles of CAR in CCl4-induced acute hepatotoxicity.METHODS: To prepare an acute liver injury model, CCl4 was intraperitoneally injected in CAR+/+ and CAR-/- mice.RESULTS: Elevation of serum alanine aminotransferase and exten

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Role of nuclear receptor CAR in carbon tetrachloride-induced hepatotoxicity

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