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孕酮拮抗剂 RU486到目前为止,主要用于终止早早孕(6～9周)。作者通过测定子宫颈组织硬度评价 RU486对人早孕期子宫颈的软化作用。42例孕期7～11周的健康孕妇选择人工流产入院治疗。孕妇平均年龄32.6岁。根据常规临床指标或超声波检查估计孕龄。真空吸引术前一周,所有病人于术前24小时和12小时随机分配口服100mgRU486或安慰剂。3例孕妇决定继续妊娠,1例孕妇因技术失误除外。其余38例孕妇中,口服 RU
The progesterone antagonist RU486 has so far been used mainly to terminate early pregnancy (6 to 9 weeks). The authors evaluate the cervix softening effect of RU486 on human early pregnancy by measuring the cervical tissue stiffness. Forty-two healthy pregnant women of 7-11 weeks during pregnancy were admitted to hospital for artificial abortion. The average age of pregnant women 32.6 years old. According to conventional clinical indicators or ultrasound examination of gestational age. One week prior to vacuum aspiration, all patients were randomly assigned to receive 100 mg of RU486 or placebo 24 hours and 12 hours prior to surgery. 3 cases of pregnant women decided to continue pregnancy, 1 case of pregnant women except for technical errors. The remaining 38 pregnant women, oral RU