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目的观察分析不同临床类型及病理免疫组化分型的垂体生长激素(GH)腺瘤患者经鼻蝶入路显微手术的临床疗效。方法回顾性分析75例经鼻蝶入路手术治疗的垂体GH腺瘤的临床资料。结果术前GH平均值为40.79mIU/L,术后为19.48mIU/L。侵袭性腺瘤40例,非侵袭性腺瘤35例。侵袭性和非侵袭性腺瘤的术后症状缓解率分别为72.5%和88.6%,复发率分别为42.5%和14.3%。结论经鼻蝶入路显微手术对垂体GH腺瘤具有较高的临床症状和内分泌缓解率。侵袭性垂体GH腺瘤,缓解率较低,复发率高,单纯GH腺瘤侵袭性明显高于其他类型GH腺瘤。
Objective To observe the clinical effects of microsurgical treatment of nasal pituitary adenomas by pituitary growth hormone (GH) adenoma with different clinical types and histopathological types. Methods The clinical data of 75 cases of pituitary adenoma treated by nasal deltoid approach were retrospectively analyzed. Results The average preoperative GH was 40.79mIU / L and 19.48mIU / L after operation. 40 cases of invasive adenoma, 35 cases of non-invasive adenoma. Postoperative symptomatic remission rates for invasive and non-invasive adenomas were 72.5% and 88.6%, respectively, with recurrence rates of 42.5% and 14.3%, respectively. Conclusions Transnasal approach microsurgery has high clinical symptoms and endocrine remission rate to pituitary adenoma. Invasive pituitary GH adenoma, low remission rate, high recurrence rate, simple GH adenoma invasiveness was significantly higher than other types of GH adenoma.