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Here presents a report on the preparation,chemical composition andphysico-chemical properties of photocarcinorin(PsD-007),a new drug ofphotolocalization and photochemotherapy for human malignancies.It was shownby the results of thin layer and high performance liquid chromatographic(TLC &HPLC)analyses that about 85% of its total weight are relatively hydrophorbicporphyrins of unknown structure,in which a fraction with the same retention timeas hematoporphyrin(Hp)monoacetate constitutes more over 60%.There are also4.2%,of Hp,8.6% of 3(8)-hydroxyethyl-8(3)-vinyl deuteroporphyrin(HVD)and0.6% of protoporphyrin(Pp)in this drug.The presence and amount of HVD inPsD 007 were determined by an authentic sample prepared by authors.Thechanges of the composition of PsD-007 on exposure to different doses of argonlaser(514.5+488nm)irradiation were detected by HPLC.The variations in Soretpeak of UV absorption spectra of PsD-007 protected from light at a constanttemperature were also determined.
Here presents a report on the preparation, chemical composition and physico-chemical properties of photocarcinorin (PsD-007), a new drug of photolocalization and photochemotherapy for human malignancies. It has been shown in the results of thin layer and high performance liquid chromatographic (TLC & HPLC) analyzes that about 85% of its total weight are relatively hydrophorbicorphorphs of unknown structure, in which a fraction with the same retention time as hematoporphyrin (Hp) monoacetate constitutes more than 60%. There are also 4.2%, of Hp, 8.6% of 3 ( 8) -hydroxyethyl-8 (3) -vinyl deuteroporphyrin (HVD) and 0.6% of protoporphyrin (Pp) in this drug.The presence and amount of HVD inPsD 007 were determined by an authentic sample prepared by authors. Thechanges of the composition of PsD-007 on exposure to different doses of argonlaser (514.5 + 488 nm) irradiation were detected by HPLC. The variations in Soretpeak of UV absorption spectra of PsD-007 protected from light at a constant temperature were also determined.