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WIF-1(Wnt inhibitory factor-1)最早作为人视网膜表达序列标签被人们所认识,后被证明是一种Wnt分子的胞外抑制剂,属于sFRP家族。WIF-1可以直接与Wnt分子结合,抑制Wnt分子与受体细胞膜上的Frizzled受体及辅助受体LRP5/6形成三聚体复合物,从而抑制了信号传导。Wif1在斑马鱼、爪蟾、小鼠和人的神经系统均有表达,参与爪蟾神经系统A-P轴的分化,影响小鼠视杆细胞的形成。Wif1在胚胎期小鼠中枢神经系统中表达强烈,提示在胚胎期神经系统发育中,Wif1可能对Wnt信号通路活性起着时空特异性的调节作用。Wnt信号通路在脊椎动物中枢神经系统发育中发挥着重要的作用,但人们对Wif1在神经系统发育中的功能却知之甚少。根据Wif1在神经发育中的表达谱信息,可以选取合适的研究时期和部位,研究Wif1在神经发育中的功能。
Wnt inhibitory factor-1 was originally recognized as a human retinal expression sequence tag and later proved to be an extracellular inhibitor of Wnt molecules belonging to the sFRP family. WIF-1 can directly bind to Wnt and inhibit the Wnt molecule from forming a trimer complex with the Frizzled receptor and its receptor LRP5 / 6 on the cell membrane of the receptor, thus inhibiting the signal transduction. Wif1 is expressed in the nervous system of zebrafish, Xenopus, mouse and human, which is involved in the A-P axis differentiation of Xenopus nerve system and affects the formation of mouse rod cells. Wif1 is strongly expressed in the central nervous system of embryonic mice, suggesting that Wif1 may play a regulatory role in regulating the Wnt signaling pathway in the embryonic nervous system. The Wnt signaling pathway plays an important role in vertebrate central nervous system development, but little is known about the function of Wif1 in the development of the nervous system. According to Wif1 expression profile in neurodevelopment, we can choose the appropriate study period and site to study the function of Wif1 in neurodevelopment.