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据报道,应用速尿可伴随庆大霉素的血浆清除率明显降低。庆大霉素清除率的降低使其在血浆内有较高的浓度,在一次快速注射给药的一小时其浓度可升高达70％。因为庆大霉素血浆浓度高可出现耳中毒症状,故具有实际的重要意义。最近进一步研究了速尿对庆大霉素清除率及其血浆浓度的影响,却得出完全不同的结论。在应用速尿后出现迅速利尿作用,且持续大约3小时之久。在此期间庆大霉素经尿排出约为其剂量的50％。单独应用庆
It is reported that the application of furosemide can be accompanied by gentamicin significantly reduced plasma clearance. Gentamicin clearance decreased to a higher concentration in plasma, up to 70% at one hour after a bolus injection. Because of high concentrations of gentamicin plasma ototoxic symptoms may occur, it has practical significance. More recently, furosemide on gentamicin clearance rate and its plasma concentration, but come to completely different conclusions. Rapid diuresis occurs after application of furosemide and lasts about 3 hours. Gentamicin excreted about 50% of its dose during this period. Apply alone celebration