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目的:观察经动脉导管化疗/栓塞术(TAI/TACE)对无手术指征胰腺癌患者的治疗效果。方法:以2011年6月至2012年10月在我院住院且无手术指征的胰腺癌患者为研究对象,根据其治疗方式分为TAI/TACE组(55例)和放化疗组(50例),观察两组治疗效果、治疗前后肿瘤标志物及炎症指标水平和生存率的差异。结果:TAI/TACE组治疗有效率明显高于放化疗组(χ2=8.788,P=0.032);治疗前两组CA19-9和IL-6、hs-CRP水平差异无显著性,治疗3个月后,两组上述指标水平均有所下降(P<0.05);TAI/TACE组1、2、3年的生存率均明显高于放化疗组(P<0.05)。结论:对无手术指征的胰腺癌患者TAI/TACE有较好的治疗效果,可明显提高患者的生存率。
Objective: To observe the effect of transcatheter arterial chemoembolization (TAI / TACE) on patients with pancreatic cancer without surgical indications. Methods: The patients with pancreatic cancer hospitalized in our hospital from June 2011 to October 2012 with no surgical indications were divided into TAI / TACE group (55 cases) and radiotherapy and chemotherapy group (50 cases ), The two groups observed the effect of treatment, before and after treatment of tumor markers and indicators of inflammation levels and survival differences. Results: The effective rate of TAI / TACE group was significantly higher than that of radiotherapy and chemotherapy group (χ2 = 8.788, P = 0.032). The levels of CA19-9 and IL-6 and hs-CRP were not significantly different between the two groups (P <0.05). The survival rates at 1, 2 and 3 years in TAI / TACE group were significantly higher than those in radiotherapy and chemotherapy group (P <0.05). Conclusion: There is a good therapeutic effect on TAI / TACE in patients with pancreatic cancer without surgical indications, which can significantly improve the survival rate of patients.