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目的 探讨猴头菇多糖对受６－２５～８－５ Ｇｙ γ射线照射小鼠的辐射防护作用。方法 给药组小鼠分别于照射前或照射后１ 小时于腹腔内注射猴头菇多糖生理盐水溶液，一次给药，剂量为３０ ｍｇ或１５ ｍｇ，观察动物的３０ 天存活情况及骨髓ＤＮＡ含量。结果 给药组的３０ 天存活率比对照组提高３５ ％ ～９７－５％ ，骨髓ＤＮＡ含量比对照组明显增加，差异均有非常显著性（ Ｐ＜０－０１） 。结论 猴头菇多糖对受照小鼠有明显的辐射防护作用，值得进一步研究。
Objective To investigate the protective effects of Hericium erinaceus polysaccharides on mice exposed to 6-25~8-5 Gy γ-rays. Methods Mice were administered intraperitoneally with Hericium erinaceus polysaccharide physiological saline solution one hour before or after irradiation. The dose was 30 mg or 15 mg. The animals were observed for 30 days survival and bone marrow DNA content. . Results The 30-day survival rate of the drug-administered group was 35% ~ 97-5% higher than that of the control group, and the DNA content of bone marrow was significantly higher than that of the control group. The difference was significant (P < 0-01). Conclusion Hericium erinaceus polysaccharide has obvious radiation protection effect on irradiated mice and it is worthy of further study.