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本文通过免疫组织化学技术对38例滋养细胞肿瘤组织 P53基因蛋白进行了检测,试图探讨 P53基因与滋养细胞肿瘤的关系。结果38例滋养细胞肿瘤中(葡萄胎10例、恶性葡萄胎10例、绒癌18例),恶葡阳性表达20%(2/10),绒癌阳性表达22.2%(4/18),有3例为高表达,10例良性葡萄胎均为阴性。结果提示:P53基因与滋养细胞肿瘤的生物学行为有密切关系。随着临床的进展,高表达增加。P53的检测可望成为预测滋养细胞肿瘤恶性发展的临床指标。
In this paper, 38 cases of trophoblastic tumor tissue P53 gene protein were detected by immunohistochemistry in order to explore the relationship between P53 gene and trophoblastic tumor. Results 38 cases of trophoblastic tumors (10 cases of hydatidiform mole, 10 cases of malignant hydatidiform mole, 18 cases of choriocarcinoma), 20% (2/10) of malignant stool positive expression, 22.2% (4/18) 3 cases were high expression, 10 cases of benign mole were negative. The results suggest that: P53 gene and trophoblastic tumor biological behavior are closely related. With the clinical progress, high expression increased. The detection of P53 is expected to become a clinical indicator to predict the malignant development of trophoblastic tumor.