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在严重心肌缺血和急性心肌梗塞演变期,肾上腺素能神经系统与心脏之间相互作用的改变,对心律失常的形成与早期的心肌细胞损害起着重要的作用。本文概述了急性心肌梗塞后几茶酚胺对心脏的长期与短期作用,以及β-肾上腺素能阻滞剂治疗作用的近展。一、心肌缺血或梗塞时α-与β-肾上腺素能受体(以下简称α与β受体)的改变及其机制:结扎狗的冠状动脉左前降支(LAD)近端1小时,引起实验性心肌缺血,用~3氚标记的
In severe myocardial ischemia and evolution of acute myocardial infarction, changes in the interaction between the adrenergic nervous system and the heart plays an important role in the formation of cardiac arrhythmias and early cardiomyocyte damage. This article provides an overview of the long-term and short-term effects of catecholamines on the heart after acute myocardial infarction, as well as the recent advances in the treatment of β-adrenergic blockers. First, myocardial ischemia or infarction α- and β-adrenoceptor (hereinafter referred to as α and β receptors) changes and its mechanism: ligation of the dog’s left anterior descending coronary artery (LAD) proximal 1 hour, causing Experimental myocardial ischemia with ~ 3 tritium labeled