Three new triterpenoids isolated from the aerial parts of Ilex cornuta and protective effects agains

来源 :Chinese Journal of Natural Medicines | 被引量 : 0次 | 上传用户:YINGWU2008
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
In the present study, three new triterpenoids, 23-hydroxyurs-12, 18-dien-28-oic acid 3β-O-α-L-arabinopyranoside(1), 23-hydroxyurs-12, 18-dien-28-oic acid 3β-O-β-D-glucuronopyranoside-6-O-methyl ester(2), and urs-12, 18-dien-28-oic acid 3β-O-β-D-glucuronopyranoside-6-O-methyl ester(3), and a known triterpenoid, 3β-hydroxy-urs-2, 18-dien-28-oic acid(4, randialic acid B), were isolated from the aerial parts of Ilex cornuta. Their structures were identified by the spectroscopic analyses(IR, ESI-MS, HR-ESI-MS, and 1D and 2D NMR) and chemical reactions. Compound 4 showed significant cell-protective effects against H_2O_2-induced H9c2 cardiomyocyte injury. Compounds 1-4 did not show any significant DPPH radical scavenging activity. In the present study, three new triterpenoids, 23-hydroxyurs-12, 18-dien-28-oic acid 3β-O-α-L-arabinopyranoside (1) 3β-O-β-D-glucuronopyranoside-6-O-methyl ester (2), and urs-12, 18- dien-28-oic acid 3β-O-β-D-glucuronopyranoside- 3), and a known triterpenoid 3β-hydroxy-urs-2, 18-dien-28-oic acid (4, randialic acid B), were isolated from the aerial parts of Ilex cornuta. Their structures were identified by the spectroscopic analyzes Compounds 4 showed significant cell-protective effects against H 2 O 2 -induced H9c2 cardiomyocyte injury. Compounds 1-4 did not show any significant DPPH radical (IR, ESI-MS, HR-ESI-MS, and 1D and 2D NMR) scavenging activity.
其他文献
为了更深入地考察淤泥的分形特性以及固化处理对淤泥分形特性的影响,以武汉市官桥湖淤泥为例,在分析淤泥扫描电镜图像的基础上,采用Matlab编程研究淤泥单元体的多重分形特性,
眼球内异物是常见的眼外伤之一。在门诊虽尽力详细检查,但仍屡见漏误诊病例发生。今就我们近期遇到的此类病例报道如下。 病例介绍 例1;曹×,男,32岁。自述工作中用铁锤敲铁
一些外胎外观完好,无破损,但内表面有裂纹.此裂纹在行车时会反复挤压内胎发生轮胎跑气.在这种情况下,只要拿来相同规格的旧内胎,取掉其气 Some of the outer appearance of
据德国DJW(经济研究所)最近完成的一项调查报告称,在过去十年间,该国投入使用的轿车,尽管其质量不断增大(由于功能上的需要不得不多采用一些零部件),但百公里燃油消耗仍然呈
张××,女,46岁。因患老年性白内障住院手术。术前以新洁尔灭消毒液冲洗双眼结膜囊,冲洗后即发现双眼结膜充血、水肿,角膜呈灰白色雾样混浊,术毕见双眼角 Zhang × ×, fem
桥梁是高速公路的主要组成部分,随着我国高速公路建设的迅速发展,桥梁里程占高速里程的比例不断升高,桥梁的类型也越来越多,高速公路桥梁检测方法和评定显得尤为重要。但随着
延长JK802C型开关寿命的一种办法北京2020轻型越野车使用了JK802C型转向灯开关,开关内采用了尼龙材料,正常的工作电流也会使尼龙熔化变形。如果线束短路或灯泡功率增大,短时间就会使开关报废。最
ALIAS/WAVEFRON世界巡回展在京举行合并后的SGI子公司ALIAS/WAVEFRON公司,于12月1日在北京举行了展览。会上,公司亚太地区经理和几位著名的设计家,影视动画制作家向来宾介绍了A/W公司情况和产品,以及未来产品Maya的发展趋势
聚晶金刚石钻头 (以下称 PDC钻头 )于 80年代问世 ,当时被誉为石油工业界的一次革命。以后虽然出现了非平面对接几何形状的聚晶金刚石薄片和切削件 ,使 PDC钻头的性能得到进
对小螺旋锥齿轮的断裂失效进行了分析。结果表明,齿轮在传动中出现偏载,造成了连续冲击过载,而使齿轮过早疲劳断裂。本文还讨论了造成偏载的可能性。 The failure of small spi