论文部分内容阅读
目的进一步研究脑血管病患者纤溶系统的功能。方法采用发色底物显色法检测，对急性脑梗塞５０例、急性脑出血３０例与正常组４０例的组织型纤溶酶原激活物（ｔ－ＰＡ）及其抑制物（ＰＡＩ）活性进行对照观察。结果脑梗塞急性期较正常对照组ｔ－ＰＡ活性明显降低（ｔ＝２４．１１，Ｐ＜０．００１），ＰＡＩ活性明显升高（ｔ＝２６．１１，Ｐ＜０．００１），脑出血急性期ｔ－ＰＡ活性显著高于正常对照组（ｔ＝１８．５６，Ｐ＜０．００１），而ＰＡＩ活性显著低于正常对照（ｔ＝２２．５２，Ｐ＜０．０１）。对急性脑梗塞病人治疗前后两项指标比较有显著差异（ｔ＝１５．７７，ｔ′＝１７．０７Ｐ均＜０．０１）。结论急性期脑梗塞及脑出血存在ｔ－ＰＡ、ＰＡＩ平衡障碍，但及时有效的治疗可以使两者平衡障碍得以改善。
Objective To further study the function of fibrinolytic system in patients with cerebrovascular disease. Methods The chromogenic substrate assay was used to detect the activity of t-PA and PAI in 50 cases of acute cerebral infarction, 30 cases of acute cerebral hemorrhage and 40 cases of normal group. Control observation. Results The t-PA activity in acute cerebral infarction group was significantly lower than that in normal control group (t = 24.11, P <0.001), PAI activity was significantly increased (t = 26.11, P <0.001) The activity of t-PA in acute phase was significantly higher than that in normal control group (t = 18.56, P <0.001), while PAI activity was significantly lower than that in control group (t = 22.52, P <0.01). The two indicators before and after treatment of patients with acute cerebral infarction were significantly different (t = 15.77, t ’= 17.07 P <0.01). Conclusions There is a balance disorder between t-PA and PAI in acute cerebral infarction and intracerebral hemorrhage. However, the prompt and effective treatment can improve the balance disorder between the two.