采用国产原子吸收分光光度计测定血液中的锂浓度,在0.05～1.50μg/ml浓度范围内吸收度和浓度呈线性,A=0.008+0.289Liμg/ml,γ=0.998,回收率测定为94.0±1.6～97.3±2.3％(加入量为0.25～0.50μg/ml):五只家兔一次口服碳酸锂12mg/kg定时取血测定锂浓度,得到的时间—药浓曲线呈显典型的二室模型,动力学参数为α=0.43h~(-1),β=0.038h~(-1),k_a=2.12h~(-1),t 1/2α=1.60h,t 1/2 β=18.1h,t(?)=1.2h,C_(max)=0.29mmol/L The concentration of lithium in the blood was determined by the domestic atomic absorption spectrophotometer. The absorbency and concentration were linear in the range of 0.05 ~ 1.50μg / ml, A = 0.008 + 0.289Liμg / ml, γ = 0.998, the recovery was 94.0 ± 1.6 ~ 97.3 ± 2.3% (0.25 ~ 0.50μg / ml): The lithium concentration of 12 rabbits in one rabbits oral administration of lithium carbonate 12mg / kg, the time-drug concentration curve showed a typical two-compartment model The kinetic parameters were α = 0.43h -1, β = 0.038h -1, k_a = 2.12h -1, t 1 / 2α = 1.60h, t 1/2 β = 18.1 h, t (?) = 1.2h, C max (max) = 0.29mmol / L