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在体外采用FeSO4/抗坏血酸自由基产生系统,发现大鼠脑组织产生的脂质过氧化物丙二醛(MDA)呈浓度依赖性增加,而其超氧化物歧化酶活性(SOD)则呈浓度依赖性降低;甘露醇和川芎嗪对此变化无明显影响,表明该体系产生的自由基以氧自由基(OFR)为主。Ⅰ号益气药黄芪对OFR所致的MDA含量增加和SOD活性降低均无明显影响;Ⅱ号活血药与黄芪和活血药组成的益气活血药Ⅲ号均可抑制OFR所致的脑组织MDA增加,但对其所致的SOD活性降低均无明显影响。结果提示,黄芪对OFR所致的脑组织脂质过氧化损伤无明显影响,活血药和益气活血药在体外可抑制OFR所致的脑组织脂质过氧化损伤,其作用与抗氧化酶无直接关系。实验未观察到黄芪与活血药配伍有明显的交互作用,提示其作用效应可能主要由活血药所表达。
Using the FeSO4/ascorbic acid free radical production system in vitro, the concentration of lipid peroxide malondialdehyde (MDA) produced in rat brain tissue was found to increase in a concentration-dependent manner, and the superoxide dismutase activity (SOD) was concentration-dependent. Sex reduction; mannitol and ligustrazine have no significant effect on this change, indicating that the free radicals produced by this system are dominated by oxygen radicals (OFR). No. I Yiqi medicine Astragalus membranaceus had no significant effect on the increase of MDA content and SOD activity caused by OFR; No. II Huoxue medicine combined with Astragalus and Huoxue medicine could improve the brain tissue MDA induced by OFR. Increased, but no significant effect on the SOD activity caused by it. The results suggest that there is no obvious effect of Astragalus on lipid peroxidation damage caused by OFR. Huoxue drugs and Yiqi Huoxue drugs can inhibit the lipid peroxidation damage caused by OFR in vitro. Direct relationship. The experiment did not observe the obvious interaction between jaundice and the active blood drug, suggesting that its effect may be mainly expressed by the active blood drug.