目的 :了解选择性 5 羟色胺再摄取抑制剂(SSRIs)氟西汀、舍曲林、帕罗西汀的不良反应特点 ,增强对 5 羟色胺 (5 HT)综合征的认识。方法 :用自制不良反应调查表对 15 0例使用上述 3药的病人发生的药物不良反应进行调查。结果 :发现有 7例出现 5 HT综合征 ,共同表现意识模糊、肌张力增高、反应迟钝、主动性减退、震颤、遗忘 ,停药才消失 ,其中 1例曾误诊为老年性痴呆 ;另 143例中失眠、头痛(头晕 )、烦躁等不良反应 ,氟西汀组高于其他 2组 ,余无差异 ,此类不良反应能自行减轻或消失。结论 :应提高对SSRIs药物不良反应的认识 ,对 5 HT综合征要与原有抑郁症状加重仔细鉴别 OBJECTIVE: To understand the adverse reaction characteristics of selective serotonin reuptake inhibitors (SSRIs) fluoxetine, sertraline and paroxetine, and to enhance the understanding of 5-HT syndrome. Methods: A self-made adverse reaction questionnaire was used to investigate adverse drug reactions in 150 patients using the above three drugs. Results: Five HT syndromes were found in seven patients. Their common manifestations were vagueness, increased dystonia, unresponsiveness, diminished initiative, tremor, forgetfulness and withdrawal. One of them had been misdiagnosed as senile dementia. Another 143 patients (Such as insomnia, headache (dizziness), irritability and other adverse reactions, fluoxetine group higher than the other two groups, I no difference, such adverse reactions can reduce or disappear. CONCLUSIONS: Awareness should be raised for adverse drug reactions in SSRIs, and careful identification of 5 HT syndrome and prior depressive symptoms should be made