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目的通过使用贝那普利联合黄葵胶囊治疗Ⅱ型糖尿病肾病(DN)轻中度蛋白尿,探讨其对Ⅱ型糖尿病肾病患者尿蛋白及血白蛋白的影响。方法将38例Ⅱ型糖尿病肾病轻中度蛋白尿患者随机分为两组:所有患者采用相同的基础治疗,治疗组在对照组基础上加用贝那普利5～20mg,既有高血压患者每日口服贝那普利10～20mg,控制血压在80～130mmHg(1mmHg=0.133kPa),无高血压患者每日口服贝那普利5mg,黄葵胶囊15粒,3次/d口服,疗程12周。结果两组患者治疗前后24h尿蛋白定量,血白蛋白差异有统计学意义(P<0.05),治疗组治疗前后24h尿蛋白定量,血白蛋白差异有统计学意义(P<0.05)。结论贝那普利联合黄葵胶囊治疗2型糖尿病肾病轻中度蛋白尿,可以明显的降低尿蛋白的产生,提升血白蛋白的含量。
Objective To investigate the effects of benazepril combined with Huang Kui capsule on type Ⅱ diabetic nephropathy (DN) mild to moderate proteinuria and its effect on urinary protein and serum albumin in patients with type Ⅱ diabetic nephropathy. Methods 38 patients with type Ⅱ diabetic nephropathy mild to moderate proteinuria were randomly divided into two groups: all patients with the same basic treatment, the treatment group on the basis of the control group plus benazepril 5 ~ 20mg, both hypertensive patients Daily oral benazepril 10 ~ 20mg, control blood pressure at 80 ~ 130mmHg (1mmHg = 0.133kPa), daily oral benazepril 5mg, Huang Kui capsule 15 capsules, 3 times / d oral, treatment 12 weeks. Results Before and after treatment, urinary protein and serum albumin had statistical significance (P <0.05). Before and after treatment, urinary protein and serum albumin had statistical significance (P <0.05). Conclusion benazepril combined with Huang Kui capsule treatment of type 2 diabetic nephropathy mild to moderate proteinuria, can significantly reduce the production of urinary protein and increase serum albumin.