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近年来前列腺癌的发病率呈上升趋势,是导致患恶性肿瘤男性死亡的主要原因之一,其早期症状不明显,20%的患者初诊时已发生转移。早期诊断率低是我国前列腺癌病死率高于欧美国家的主要原因。前列腺癌患者的血液、尿液、精液中存在着特异性和敏感性较高的诊断标志物,如早期前列腺癌抗原、ERG蛋白、基质金属蛋白酶9、GSTP1甲基化等,联合检测可以提高前列腺癌早期诊断率,做到早发现、早治疗,为患者的治疗提供机会,进一步延长患者的生存期。
In recent years, the incidence of prostate cancer is on the rise, which is one of the major causes of death of male patients with malignant tumors. The early symptoms are not obvious. Twenty percent of the patients have already had their first visit. The low rate of early diagnosis of prostate cancer in China is higher than the major causes of mortality in Europe and the United States. Prostate cancer patients with blood, urine, semen there is a high specificity and sensitivity of diagnostic markers, such as early prostate cancer antigen, ERG protein, matrix metalloproteinase 9, GSTP1 methylation, joint detection can improve the prostate Early diagnosis of cancer, so early detection and early treatment, provide the opportunity for the treatment of patients to further extend the patient’s survival.