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目的 :探讨血清总胆汁酸 (TBA)、Ⅲ型前胶原 (PCⅢ )、Ⅳ型胶原 (Ⅳ -C)、透明质酸 (HA)、甘胆酸 (CG)及层粘连蛋白 (LN)联检在慢性肝病诊断中的价值。方法 :1 1 8例乙型肝炎患者和 31例健康对照组采用放射免疫分析法 (RIA)测定PCⅢ、Ⅳ -C、HA、CG及LN和全自动酶法测定血清TBA。结果 :肝纤维化组血清TBA及肝纤维化五项指标水平较正常组明显升高 (p <0 0 1 ) ,而各组间随肝病组织炎症程度增加 ,检测指标水平也相应增高。结论 :血清TBA与肝纤维化五项指标的联检对肝纤维化的诊断、治疗及预后判断有重要意义。
Objective: To investigate the correlation between serum total bile acid (TBA), type Ⅲ procollagen (PC Ⅲ), type Ⅳ collagen (Ⅳ -C), hyaluronic acid (HA), glycocholic acid (CG) and laminin The value of diagnosis of chronic liver disease. Methods: The serum levels of TBA were measured by radioimmunoassay (RIA) and PCⅢ, Ⅳ-C, HA, CG and LN in 118 healthy subjects and 31 healthy controls. Results: The levels of serum TBA and hepatic fibrosis in liver fibrosis group were significantly higher than those in normal group (p <0.01). However, the levels of inflammatory markers increased with the severity of hepatic disease in all groups. Conclusion: The joint examination of serum TBA and liver fibrosis five indexes is of great significance for the diagnosis, treatment and prognosis of liver fibrosis.