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方法 将Spraque-Dawley雄鼠分成四组:CONT(对照)组、ADR(阿霉素治疗)组、PRoB(丙丁酚治疗)组和PROB+ADR(丙丁酚加阿霉素治疗)组。ADR和PROB+ADR组,两周内隔天腹腔注射阿霉素共6次(每次2.5mg/kg)。PROB和PROB+ADR组,四周内隔天腹腔内注射PROB共12次(每次10mg/kg),后两周内隔天腹腔内注射阿霉素(与PROB交替)共6次(累积量15mg/kg)。处理结束后观察3周,统计死亡率并最后测定动物的血流动力学指标。 结果 ADR组治疗结束后3周出现了以腹水、肝郁血、心功能减退、左室舒张末压升高和心肌细胞损害为特征的心肌病和充血性心衰。心肌谷胱甘肽过氧化物酶(GSH-
Methods Spraque-Dawley male rats were divided into four groups: CONT (control), ADR (doxorubicin), PRoB (probucol) and PROB + ADR (probucol plus doxorubicin) groups. ADR and PROB + ADR group, intraperitoneal injection of doxorubicin a total of 6 times (2.5mg / kg each time) within two weeks. PROB and PROB + ADR groups were injected intraperitoneally with PROB for 12 times (every 10 mg / kg) every other day for four weeks. Adriamycin (alternately with PROB) / kg). After treatment for 3 weeks, the mortality was calculated and the hemodynamics of the animals were finally measured. Results Cardiomyopathy and congestive heart failure characterized by ascites, hepatic depression, impaired cardiac function, increased left ventricular end-diastolic pressure, and cardiomyocyte damage occurred 3 weeks after the end of treatment in the ADR group. Myocardial glutathione peroxidase (GSH-