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①目的 探讨２型糖尿病伴发高血压病人胰岛β细胞早期分泌相的变化规律。②方法 采用精氨酸兴奋试验及放免法，分别检测了８２ 例２ 型糖尿病病人空腹及左旋精氨酸（Ｌ－ＡＲＧ）刺激后２，４，６ｍ ｉｎ 时胰岛素（ＩＮＳ）和Ｃ肽（Ｃ－Ｐ）水平变化，并与５０ 例健康人进行对照。③结果 伴发高血压的２ 型糖尿病组空腹ＩＮＳ水平明显高于对照组和无血管病变组（Ｆ＝ ９．４１，ｑ＝ ３．９１，６．０７，Ｐ＜ ０．０１）；其Ｃ－Ｐ水平亦明显高于无血管病变组（Ｆ＝９．３３，ｑ＝ ５．８９，Ｐ＜ ０．０１）；Ｌ－ＡＲＧ刺激后无血管病变及伴发高血压的２ 型糖尿病组ＩＮＳ和Ｃ－Ｐ分泌均在２ｍ ｉｎ 时达峰值；２ 型糖尿病伴发高血压组２，４，６ｍ ｉｎ 时的ＩＮＳ，Ｃ－Ｐ分泌值均明显高于无血管病变组（Ｆ＝ １５．４２～７９．０２，ｑ＝ ３．１１～６．３１，Ｐ均＜ ０．０５，０．０１）；合并高血压的２ 型糖尿病伴有肥胖组空腹ＩＮＳ及Ｌ－ＡＲＧ兴奋后ＩＮＳ，Ｃ－Ｐ峰值均明显高于非肥胖组（ｔ＝ ２．５２～７．２４，Ｐ＜ ０．０５，０．０１）。④结论 伴发高血压的２ 型糖尿病病人存在较严重的胰岛素抵抗（ＩＲ），伴有肥胖者更明显。ＩＲ及胰岛β细胞早期分泌功能的紊乱与２ 型糖
Objective To investigate the changes of the early phase of pancreatic β cells in type 2 diabetic patients with hypertension. Methods The arginine excitability test and radioimmunoassay were used to detect the levels of insulin (INS) and C-peptide (C) in 82 patients with type 2 diabetes mellitus at 2,4 and 6 mins after fasting and L-arginine -P) levels, and compared with 50 healthy people. Results The level of fasting insulin (INS) in type 2 diabetes mellitus patients with hypertension was significantly higher than that in control group and non-vascular disease group (F = 9.41, q = 3.91,6.07, P <0.01) -P levels were also significantly higher in patients with type 2 diabetes mellitus without vascular disease and with hypertension after L-ARG stimulation (F = 9.33, q = 5.89, P <0.01) And C-P secretion peaked at 2m in. The secretions of INS and C-P at 2, 4 and 6m in type 2 diabetic patients with hypertension were significantly higher than those without vascular disease (F = 15.42 ~ 79.02, q = 3.11 ~ 6.31, P <0.05, 0.01). In type 2 diabetes mellitus patients with hypertension associated with obesity group, INS and C- P peak were significantly higher than non-obese group (t = 2.52 ~ 7.24, P <0.05,0.01). ④ Conclusion Type 2 diabetes patients with hypertension have more severe insulin resistance (IR), with obesity more obvious. Disorders of IR and beta-cell early secretory function with type 2 glucose