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用两种惊厥模型,通过跳台法和避暗法观察了临床常用的几种抗癲痫药抗惊厥作用,以及对学习记忆的影响。结果表明:对抗马桑内酯惊厥,以硝基安定和氯硝基安定效果最好,苯巴比妥及丙戊酸钠次之,酰胺咪嗪和芹菜甲素无效,而苯妥英钠及抗痫灵则能加重惊厥;在电惊厥模型中,以苯妥英钠和苯巴比妥效果最佳,丙戊酸钠及酰胺咪嗪次之,其它药物无效;除芹菜甲素外,其余七种药物均能削弱记忆获得。硝基安定和氯硝基安定可保护马桑内酯惊厥对记忆的损害,而硝基安定能加重电惊厥对记忆的损害。
Using two kinds of convulsions model, the anti-convulsive effect of several anti-epileptic drugs commonly used in clinic and their effects on learning and memory were observed by the method of jumping and avoiding darkness. The results showed that anticonvulsant had the best anticonvulsant effect against clonazepam with nitrazepam and clonazepam followed by phenobarbital and valproate, followed by amiloride and celerychin, while phenytoin and antiepileptic The spirit can aggravate convulsions; electroconvulsive model, phenytoin sodium and phenobarbital best, followed by sodium valproate and amidipramine, other drugs ineffective; except celery a, the remaining seven drugs are Can weaken the memory to get. Nitrazepam and clonazepam protect the memory impairment of the coronatine convulsions, and nitrazepam aggravates the memory impairment of electroconvulsions.