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目的综合评价基质金属蛋白酶9(matrix metalloproteinase-9,MMP-9)基因1562C/T多态性与中国汉族人群冠心病(coronary heart disease,CHD)的关系。方法中文文献以中国学术期刊网(CNKI)全文数据库、重庆维普(VIP)中文科技期刊全文数据库、万方科技期刊全文数据库作为检索数据库,英文文献以Medline、Pubmed、Embase作为检索数据库,检索2011年1月前发表的关于中国汉族人群MMP-9基因1562C/T多态性与CHD关系的病例对照研究文献,应用state11软件进行Meta分析。结果共纳入8篇病例对照研究文献,病例组1661人,对照组1481人。Meta分析表明,中国汉族人群MMP-9基因1562T等位基因与冠心病的发病相关(OR=1.74,95%CI:1.31～2.30)。携带TT基因型的个体发生冠心病的危险性是非TT基因型人群的2.63倍(OR=2.63,95%CI:1.34～5.16)。携带TT基因型的个体发生冠心病的危险性是携带CC基因型个体的2.96倍(OR=2.96,95%CI:1.51～5.79)。敏感性分析显示结果稳定;Begg、Egger检验提示无发表偏倚。结论我国汉族人群MMP-9基因1562C/T多态性与冠心病发病相关,T等位基因可能是冠心病易感性的标记基因之一。
Objective To evaluate the relationship between 1562C / T polymorphism of matrix metalloproteinase-9 (MMP-9) gene and coronary heart disease (CHD) in Chinese Han population. Methods The Chinese literature was searched with CNKI full-text database, VIP database of Chinese science and technology of Chongqing, Wanfang periodical full-text database and English database with Medline, Pubmed and Embase as search databases. A case-control study of the association between the 1562C / T polymorphism of the MMP-9 gene and CHD in Chinese Han population published January 1 was conducted using the state11 software for meta-analysis. Results A total of 8 case-control studies were included, including 1661 cases and 1481 controls. Meta-analysis showed that the 1562T allele of MMP-9 gene in Chinese Han population was associated with the incidence of coronary heart disease (OR = 1.74, 95% CI: 1.31-2.30). Individuals with the TT genotype had a 2.63-fold risk of developing coronary heart disease (OR = 2.63, 95% CI: 1.34 to 5.16) in non-TT genotype populations. Individuals carrying the TT genotype had a 2.96-fold increased risk of coronary heart disease (OR = 2.96, 95% CI: 1.51 to 5.79) in individuals with CC genotypes. Sensitivity analysis showed stable results; Begg, Egger test showed no publication bias. Conclusion The 1562C / T polymorphism of MMP-9 gene in Chinese Han population is associated with the pathogenesis of coronary heart disease, and the T allele may be one of the markers of coronary heart disease susceptibility.