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研究目的本研究旨在了解慢性肺心病患者的左心室功能改变。研究背景尽管早在1962年Altschule即已提出慢性肺心病是一全心疾病,但以后有关研究甚少,至今对慢性肺心病患者的左心室功能改变仍不清楚。方法用心阻抗血流图法对30例慢性肺心病患者进行左心室功能检测,并与30例正常人对照。同时还对慢性肺心病患者心脏指数(CI)与左心室收缩功能及舒张功能参数之间的关系作了相关分析。结果慢性肺心病患者的左心室射血前期(PEP)延长,射血期(LVET)缩短,PEP/ET值增大,射血分数(LVEF)减低,等容舒张期(IRT)延长,房缩波(A)增高,房缩波与室缩波之比值(A/C)增大,CI减低;与急性发作期比较,缓解期上述大部分参数的异常程度均有一定减轻;相关分析显示CI与IRT、A/C 的相关性优于与PEP/LVET、LVEF的相关性。结论结果表明慢性肺心病患者存在显著的左心室功能障碍,左心室舒张功能的异常出现较早、程度较重。
Purpose of the study This study aimed to understand the changes of left ventricular function in patients with chronic cor pulmonale. BackgroundAlthough as early as 1962, Altschule proposed that chronic pulmonary heart disease is a generalized heart disease, little research has been done since then. So far, the change of left ventricular function in patients with chronic cor pulmonale remains unclear. Methods Thirty patients with chronic pulmonary heart disease were tested for left ventricular function by impedance impedance blood flow diagram and compared with 30 healthy controls. The relationship between cardiac index (CI) and left ventricular systolic and diastolic parameters in patients with chronic cor pulmonale was also analyzed. Results Patients with chronic cor pulmonale had prolonged left ventricular ejection fraction (PEP), shortened ejection duration (LVET), increased PEP / ET, decreased ejection fraction (LVEF), prolonged isovolumic relaxation (IRT) (A) increased, the ratio of A / C to A / C increased and CI decreased. Compared with the acute episode, the abnormality of most of the above parameters was alleviated. Correlation analysis showed that CI Correlations with IRT and A / C were better than those with PEP / LVET and LVEF. Conclusion The results show that there is significant left ventricular dysfunction in patients with chronic cor pulmonale, and the abnormality of left ventricular diastolic function occurs earlier and to a greater extent.