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研究了~(117)Sn~m(Ⅳ)及~(117)Sn~m(Ⅳ)-EDTMP在体外骨模型羟基磷灰石(HA)上的吸附及解吸特性,探讨了其骨吸附机理。吸附研究表明:~(117)Sn~m(Ⅳ)及~(117)Sn(Ⅳ)-EDTMP在HA上都有明显的吸附,其对~(117)Sn~m(Ⅳ)的吸附量大于对~(117)Sn~m(Ⅳ)-EDTMP的吸附量;pH对吸附有明显影响,酸性条件最有利于吸附,弱碱性条件最不利于吸附;温度对吸附几乎没有影响。解吸研究表明:生理盐水和EDTMP对~(117)Sn~m(Ⅳ)-EDTMP的解吸量大于对~(117)Sn~m(Ⅳ)的解吸量。~(117)Sn~m(Ⅳ)-EDTMP的吸附机理研究初步表明:当吸附量小于60μmol/g时,络合物以整个配位络合物吸附为主;当吸附量大于60μmol/g时,配位络合物整体吸附与~(117)Sn~m(Ⅳ)从配体到HA的转移络合同时存在。
The adsorption and desorption properties of ~ (117) Sn ~ m (Ⅳ) and ~ (117) Sn ~ m (Ⅳ) -EDTMP on hydroxyapatite (HA) were studied. Adsorption studies show that the adsorption of ~ (117) Sn ~ m (Ⅳ) and ~ (117) Sn (Ⅳ) -EDTMP on HA are obvious, The adsorption capacity of ~ (117) Sn ~ m (Ⅳ) -EDTMP was obvious. PH had a significant effect on the adsorption. Acidic conditions were the most favorable for adsorption and the weakly alkaline conditions were the least suitable for adsorption. Temperature had little effect on adsorption. Desorption studies showed that desorption amount of ~ (117) Sn ~ m (Ⅳ) -EDTMP by saline and EDTMP was greater than that of ~ (117) Sn ~ m (Ⅳ) desorption. The adsorption mechanism of ~ (117) Sn ~ m (Ⅳ) -EDTMP initially showed that when the adsorption amount was less than 60μmol / g, the complex was mainly adsorbed on the entire coordination complex. When the adsorption amount was more than 60μmol / g The overall adsorption of the coordination complex and the transition complexation of ~ (117) Sn ~ m (Ⅳ) from the ligand to the HA co-exist.