论文部分内容阅读
目的:探讨少腹逐瘀汤内服联合康复新液灌肠治疗血瘀肠络型溃疡性结肠炎(UC)的疗效及对活化部分凝血活酶时间(APTT)和纤维蛋白原(FIB)的影响。方法:将我院收治70例UC患者随机分为对照组35例和治疗组35例。对照组给予柳氮磺吡啶肠溶片;治疗组在对照组基础上给予少腹逐瘀汤治疗,常规水煮分2早晚两次内服,康复新液保留灌肠,2次/日,每次30分钟。两组疗程均4周。比较两组主要症状积分、黏膜病变活动指数(Sutherland DAI)积分及临床疗效;测定两组凝血功能指标APTT和FIB。结果:治疗后,治疗组主要症状各指标积分和Sutherland病变活动指数评分均明显少于对照组(P<0.01);治疗组临床疗效总有效率为93.18%,明显高于对照组75%(χ2=4.928,P<0.05);治疗后,治疗组患者APTT明显高于对照组,FIB明显低于对照组,差异均有统计学意义(P<0.01)。结论少腹逐瘀汤内服联合康复新液灌肠治疗血瘀肠络型UC的疗效明显,改善患者的高凝血状态可能与其治疗作用相关。
Objective: To investigate the therapeutic effect of Shaofuzhuyu decoction combined with Kangfuxin solution on stasis ulcerative colitis (UC) and its effect on activated partial thromboplastin time (APTT) and fibrinogen (FIB). Methods: 70 cases of UC patients admitted to our hospital were randomly divided into control group 35 cases and treatment group 35 cases. The control group was given sulfasalazine enteric-coated tablets. The treatment group was treated with Shaofuzhuyu Decoction on the basis of the control group. The routine boiling water was given orally twice daily in morning and evening, minute. Two courses of treatment are 4 weeks. The scores of major symptom scores, mucosal lesion activity index (Sutherland DAI) scores and clinical curative effect were compared between two groups. APTT and FIB were measured in two groups. Results: After treatment, the score of each index of major symptoms and Sutherland’s disease activity index of the treatment group were significantly less than that of the control group (P <0.01). The total effective rate of the treatment group was 93.18%, significantly higher than that of the control group (χ2 = 4.928, P <0.05). After treatment, APTT in treatment group was significantly higher than that in control group, FIB was significantly lower than that in control group (P <0.01). Conclusion Oral administration of Shaofuzhuyu decoction combined with Kangfuxin solution enema has obvious curative effect on UC with blood stasis type UC, and the improvement of hypercoagulable state in patients may be related to its therapeutic effect.