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现在认为甲亢母亲出生的新生儿暂时性甲亢(TNH),是母亲甲状腺刺激免疫球蛋白经胎盘传给婴儿的结果。现已证实某些甲亢患者血清免疫球蛋白,抑制甲状腺刺激激素与其受体位置结合,因而称为甲状腺刺激激素结合抑制的免疫球蛋白(TBⅡ)。也证明了患者血清免疫球蛋白刺激人类甲状腺组织产生cAMP(环磷腺苷),并认为是甲状腺刺激抗体(TSAb)。作者研究3例甲亢孕妇出生的婴儿,其中1例发生典型的TNH。作者测定这3例婴儿及其母亲的血清TBⅡ和TSAb浓度。
Newborn transient hyperthyroidism (TNH), now considered a hyperthyroid mother, is the result of a mothers thyroid-stimulated immunoglobulin delivered to the infant via the placenta. It has been confirmed that some patients with hyperthyroidism serum immunoglobulin, thyroid stimulating hormone and its receptor binding position, which is called thyroid stimulating hormone binding inhibition of immunoglobulin (TB Ⅱ). It has also been demonstrated that patient serum immunoglobulins stimulate human thyroid tissue to produce cAMP (cyclic adenosine monophosphate) and is considered a thyroid stimulating antibody (TSAb). The authors studied 3 infants born to pregnant women with hyperthyroidism, one of which developed typical TNH. The authors measured serum TB II and TSAb concentrations in these 3 infants and their mothers.