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患者女,48岁,因非胰岛索依赖性糖尿病和已控制的精神分裂症及腹股沟皮疹加重入院.体检可见外阴、会阴及股内侧广泛的红斑、浸渍,周围布以脓胞并可查见假菌丝.予酮康唑400mg/d,局部常规治疗,以胰岛素控制血糖.4天后皮损恢复迅速而出院.继续服同量酮康唑,2周发现5′-核苷酸酶和碱性磷酸酶升高,转氨酶正常,乃停服酮康唑,改为酮康唑霜外用,但3周后皮损加重.开始用氟康唑(fluconazole)门诊治疗,100mg/d口服,4周后皮损明显改善,且停药1月未见复发.随访2月余仅有轻微复发(再用该药100mg/d 1周得以治愈).此后即以200mg/月量维持.治疗期间肝功能检查仅轻度异常但无症状而血糖仍
The woman, 48, was admitted to hospital for non-insulin dependent diabetes mellitus and controlled schizophrenia and inguinal rash. Physical examination revealed extensive erythema in the vulva, perineum, and medial femoral strands, impregnated with pus and surrounded by pus and examined for falsehood Mycelium.Confused with ketoconazole 400mg / d, local routine treatment, insulin control of blood glucose.4 days after the rapid recovery of skin lesions and continue to take the same amount of ketoconazole, two weeks found 5’-nucleotidase and alkaline Phosphatase increased, transaminases normal, but stopped taking ketoconazole, ketoconazole to external use, but after 3 weeks of skin lesions increased.Fluconazole (fluconazole) outpatient treatment, 100mg / d oral, 4 weeks after the lesion Significantly improved, and no recurrence of withdrawal in January 1. More than 2 months follow-up only a slight recurrence (re-use of the drug 100mg / d 1 week to be cured.) Then 200mg / month maintenance. Liver function tests during treatment only light Abnormal but asymptomatic and blood glucose still