目的建立顶空气相色谱法测定埃索美拉唑钠中7种有机溶剂残留量的方法。方法采用DB-624(30 m×530μm,3μm)毛细管柱,经程序升温,氢火焰离子化检测器检测,载气为氮气。结果乙醇、丙酮、异丙醇、乙腈、二氯甲烷、甲基叔丁基醚及甲苯在考察范围内线性关系良好(r≥0.999 0),平均回收率为89.7%～104.6%,检测限分别为1.40、0.39、1.60、1.10、0.74、0.04、0.16 mg.L-1。结论本方法可用于埃索美拉唑钠中残留溶剂的检查。 Objective To establish a method for the determination of 7 organic solvents in esomeprazole sodium by headspace gas chromatography. Methods The capillary column DB-624 (30 m × 530μm, 3μm) was used. The temperature was programmed and hydrogen flame ionization detector was used. The carrier gas was nitrogen. Results The linear relationship between ethanol, acetone, isopropanol, acetonitrile, methylene chloride, methyl tert-butyl ether and toluene was good (r≥0.999 0) and the average recoveries were 89.7% -104.6% 1.40, 0.39, 1.60, 1.10, 0.74, 0.04, 0.16 mg.L-1. Conclusion This method can be used for the determination of residual solvents in esomeprazole sodium.