帕金森氏病(parkinson′s disease,PD)是一种以黑质多巴胺能神经元散失和细胞浆出现Lewy小体为特征的神经系统退变性疾病。大多数PD患者是散发的,家族性PD尽管罕见,但其致病基因的鉴定是深入了解该病发病机制的重要途径。这些基因(编码α-synuclein、parkin、UCH-L1和DJ-1蛋白) Parkinson’s disease (PD) is a degenerative nervous system characterized by the loss of substantia nigra dopaminergic neurons and the presence of Lewy bodies in the cytoplasm. Most patients with PD are excreted, although familial PD rare, but its pathogenic gene identification is an important way to understand the pathogenesis of the disease. These genes (encoding α-synuclein, parkin, UCH-L1 and DJ-1 proteins)