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女患,14岁。因多发性关节炎和皮肤损害三个月,抗核抗体阳性而诊断为系统性红斑狼疮。尿沉渣镜检:多量红、白细胞,可见透明和颗粒管型。尿蛋白(++++)。尿素氮22mg%,白蛋’白1.9g%,胆固醇350mg%。肌酐廓清率85ml/分,24小时尿蛋白定量为4～8g。查体可见多发性关节炎,眼眶周围和下肢水肿。肾活检为弥漫性膜增殖型肾小球肾炎。给予大剂量甲强的松龙静脉滴注,每日1,000mg,
Female suffering, 14 years old. Because of multiple arthritis and skin lesions for three months, anti-nuclear antibodies positive and diagnosed with systemic lupus erythematosus. Urine sediment microscopy: a large amount of red, white blood cells, visible and transparent granular tube. Urinary protein (++++). Urea nitrogen 22mg%, white egg white 1.9g%, cholesterol 350mg%. Creatinine clearance rate of 85ml / min, 24-hour urine protein quantitative 4 ~ 8g. Physical examination showed multiple arthritis, periorbital and lower extremity edema. Renal biopsy for diffuse proliferative glomerulonephritis. Give a large dose of prednisolone intravenous infusion, daily 1,000mg,