论文部分内容阅读
目的观察谷氨酰胺对卒中患者免疫功能的影响。方法卒中40例,随机分成谷氨酰胺组和对照组,每组20例,采用随机双盲法,谷氨酰胺组每日分2次口服L-谷氨酰胺10 g,对照组给予相同剂量安慰剂,实验期7 d,于给药后第8天分别抽取两组患者外周静脉血1次,检测免疫功能指标:外周静脉血IgAI、gMI、gG,外周静脉血CD3+细胞比例、CD4+细胞比例、CD8+细胞比例以及CD4+/CD8+,外周静脉血IL-2、NO、TNF-α含量。结果谷氨酰胺组患者外周静脉血IgAI、gMI、gG浓度,外周静脉血CD3+、CD4+、CD4+/CD8+比例,外周静脉血IL-2、NO含量均高于对照组(P<0.05或P<0.01),而TNF-α含量低于对照组(P<0.05)。结论谷氨酰胺对卒中患者免疫功能有一定的改善作用。
Objective To observe the effect of glutamine on immune function in stroke patients. Methods 40 cases of stroke were randomly divided into glutamine group and control group, 20 cases in each group. Randomized double-blind method was used. Glutamine group was orally administered with L-glutamine 10 g twice a day, and the control group was given the same dose of stimulation The experimental group was given intravenous blood once a day for 7 days on the 8th day after the administration to measure the immune function indexes such as IgAI, gMI, gG in peripheral venous blood, proportion of CD3 + cells in peripheral venous blood, proportion of CD4 + cells, CD8 + cell ratio and CD4 + / CD8 +, peripheral venous blood IL-2, NO, TNF-α content. Results The levels of IgAI, gMI, gG in peripheral venous blood and the levels of CD3 +, CD4 + and CD4 + / CD8 in peripheral venous blood and IL-2 and NO in peripheral venous blood of patients in glutamine group were significantly higher than those in control group (P <0.05 or P <0.01) ), While the level of TNF-α was lower than that of the control group (P <0.05). Conclusion Glutamine can improve the immune function in patients with stroke.