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脑转移癌姑息性放疗虽可收到解除神经症状和改善病人存活质量的结果,但结果仍很不理想,放疗后病人的中数存话时间只有10～40周。为研究脑转移癌姑息性放疗不同剂量的结果,参加美国肿瘤放疗协作组的31个医疗单位从1976年5月到1979年8月共提供脑转移癌309例,将其中只有单个转移灶的225例进行随机分组研究。分为3000拉德组(3000拉德/10次/2周)和5000拉德组(5000拉德/20次/4-5周)。为估计疗效,观察的项目为:死亡原因、中数存话时间、神经症状的改善及放疗后症状改善的中数时间。
Although palliative radiotherapy for metastatic carcinoma of the brain may result in the relief of neurological symptoms and improvement of the patient’s quality of life, the results are still unsatisfactory. The median number of patients in radiotherapy after radiotherapy is only 10 to 40 weeks. In order to study the results of different doses of palliative radiotherapy for brain metastases, 309 cases of brain metastases were provided from 31 medical units participating in the American Cancer Radiotherapy Cooperative Group from May 1976 to August 1979, and 225 of them had only one metastasis. Cases were randomized into groups. It was divided into a 3000 rad group (3000 rad/10 times/2 weeks) and a 5000 rad group (5000 rad/20 times/4-5 weeks). To estimate the efficacy, the observed items were: the cause of death, the number of minutes in the room, the improvement of neurological symptoms, and the median time for symptom improvement after radiotherapy.