论文部分内容阅读
目的研究临床分离念珠菌的特征及其耐药性,为合理用药提供参考依据。方法采用真菌分离鉴定技术和药敏试验方法,对某医院住院患者临床送检标本进行念珠菌种类调查和耐药性分析。结果调查期间从该医院临床送检病原学标本中,共检出念珠菌497株,分离菌株数居前三位的科室是呼吸科、重症监护病房和神经内科。有54.33%的菌株分离自呼吸道标本,另有16.70%的标本为泌尿生殖道标本。临床分离的念珠菌主要是白色念珠菌,占62.78%,其次是光滑念珠菌。临床分离的念珠菌对5-氟胞嘧啶和两性霉素B敏感率较高,但耐药率呈现逐年增加趋势。结论临床分离的念珠菌多数为白色念珠菌,主要为呼吸道感染,对抗念珠菌药敏感率均在60%以上,但耐药性有增加趋势。
Objective To study the characteristics and drug resistance of Candida isolated clinically and provide reference for rational drug use. Methods Fungal isolation and identification techniques and susceptibility testing methods were used to investigate Candida species and drug resistance in clinical specimens of hospitalized patients in a hospital. Results During the investigation, 497 strains of candida were found in the etiological specimens of clinical examination in this hospital. The departments with the top three isolates were respiratory department, intensive care unit and neurology. 54.33% strains were isolated from respiratory specimens, and another 16.70% specimens were genitourinary tract specimens. Clinical Candida albicans is mainly Candida albicans, accounting for 62.78%, followed by Candida glabrata. Clinically isolated Candida sensitive to 5-fluorocytosine and amphotericin B, but the drug resistance showed a trend of increasing year by year. Conclusions Candida albicans is mostly Candida albicans, mainly respiratory tract infections. The sensitivity to Candida albicans is over 60%, but the drug resistance tends to increase.