以非平衡热力学分离理论为框架,建立了毛细管电泳分离大系统的分离模型.以分离过程的操作电压U为控制量,以溶质体系的净分离熵S_S作为目标函数,通过对分离大系统的优化设计,得到了最优操作电压控制轨线U~(?)(t).通过仿真,证明了分离大系统在此最优控制规律作用下,分离效果最好. Based on the theory of non-equilibrium thermodynamic separation, a separation model of capillary electrophoresis separation system is established. Taking the operating voltage U of the separation process as the control volume and the net separation entropy S_S of the solute system as the objective function, the optimization of the separation system Design and get the optimal operating voltage control trajectory U ~ (?) (T). Through simulation, it is proved that the separation system works best under this optimal control law.