胰岛素样生长因子的前身为非抑制性胰岛素样活性(NAILA),是Froesch于1963年在人血清中发现的。后来Humbel和Rinderknecht以测序的方式发现了NAILA中不同的生长因子,因为它们在结构功能及作用上均与胰岛素十分相似,故于1976年被正式命名为胰岛素样生长因子(IGF),包括IGF1和IGF2。IGF2也称为生长调节素,既是一种胚胎生长 Insulin-like growth factor, formerly known as non-inhibitory insulin-like activity (NAILA), was discovered by Froesch in human serum in 1963. Humbel and Rinderknecht later discovered by sequencing different growth factors in NAILA because they were structurally similar in function and function to insulin and were therefore formally named insulin-like growth factors (IGFs) in 1976, including IGF1 and IGF2. IGF2, also known as somatomedin, is both an embryonic growth