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目的探讨血必净联合大剂量甲泼尼龙琥珀酸钠治疗急性百草枯中毒患者的临床疗效及安全性。方法 52例口服百草枯中毒患者随机分为治疗组及对照组,各26例,对照组患者仅给予常规治疗及血液灌流治疗。治疗组患者在常规治疗基础上联合应用血必净注射液和静脉注射甲泼尼龙琥珀酸钠,比较两组的治疗效果。结果治疗组患者治疗7 d后,动脉血氧分压、血清生化指标、C-反应蛋白均明显优于对照组,两组比较差异有统计学意义(P<0.05)。治疗组患者病死率明显小于对照组,两组比较差异有统计学意义(P<0.05)。结论血必净联合大剂量甲泼尼龙琥珀酸钠早期应用可减小百草枯对重要脏器功能的损害,降低急性百草枯中毒的病死率,可在临床上推广使用。
Objective To investigate the clinical efficacy and safety of Xuebijing combined with high-dose methylprednisolone sodium succinate in the treatment of acute paraquat poisoning. Methods Fifty-two patients with oral paraquat poisoning were randomly divided into treatment group and control group, with 26 cases in each group. Patients in control group were given routine treatment and hemoperfusion only. The patients in the treatment group were treated with Xuebijing injection and methylprednisolone sodium succinate on the basis of routine treatment. The therapeutic effects of the two groups were compared. Results After 7 days of treatment, arterial partial pressure of oxygen, serum biochemical index and C-reactive protein in the treatment group were significantly better than those in the control group. There was significant difference between the two groups (P <0.05). The treatment group patients mortality was significantly less than the control group, the difference between the two groups was statistically significant (P <0.05). Conclusion Xuebijing combined with high-dose methylprednisolone sodium succinate early application can reduce paraquat damage to vital organs function, reduce the mortality of acute paraquat poisoning, which can be widely used in clinic.