论文部分内容阅读
目的通过测定冠状动脉慢血流(CSF)者血浆同型半胱氨酸(Hcy)、血小板一氧化氮(NO)及其合酶(NOS)的变化,探讨它们与CSF发生机制的关系。方法选择经冠状动脉造影(CAG)检查诊断为CSF者20例(CSF组),CAG示无管腔狭窄及无慢血流者20例作为对照(NCF组),采用校正的TIMI血流分级(CTFC)方法评价冠状动脉血流速度,并测定其血浆Hcy、血小板NO含量、NOS活性、血小板计数(Plt)、血小板体积分布宽度(MPV)、平均血小板体积(PDW)。结果两组患者Plt、MPV、PDW比较无显著性差异(P﹥0.05);CSF组血浆Hcy水平[(17.92±5.86)μmol/L]明显高于NCF组[(11.42±4.28)μmol/L](P﹤0.001);血小板NO含量、NOS活性[(0.40±0.33)μmol/gprot,(1.69±0.15)U/mgprot]较NCF组[(1.27±0.8)μmol/gprot,(2.17±0.21)U/mgprot]明显减低(P﹤0.05)。结论增高的血浆Hcy水平使冠状动脉内皮功能受损,导致血小板功能受损,可能与CSF现象发生有关。
OBJECTIVE: To investigate the changes of plasma homocysteine (Hcy), nitric oxide (NO) and synthase (NOS) in patients with chronic coronary artery disease (CSF) and their relationship with the pathogenesis of CSF. Methods Twenty patients (CSF group) diagnosed as CSF by coronary angiography (CAG) were selected. Twenty patients without lumen stenosis and no slow blood flow were selected as control group (NCF group) by CAG. The corrected TIMI grade (CTFC) were used to evaluate the coronary flow velocity. Plasma Hcy, NO content, NOS activity, Plt, MPV, and PDW were measured. Results There was no significant difference in Plt, MPV and PDW between the two groups (P> 0.05). The level of plasma Hcy in CSF [(17.92 ± 5.86) μmol / L] was significantly higher than that in NCF [(11.42 ± 4.28) μmol / L] (P <0.001). Compared with NCF group (1.27 ± 0.8) μmol / gprot and (2.17 ± 0.21) U, the levels of NO and NOS in platelet [(0.40 ± 0.33) μmol / gprot, / mgprot] was significantly reduced (P <0.05). Conclusion Increased plasma Hcy levels impaired endothelial function of coronary arteries and impaired platelet function, which may be related to the occurrence of CSF.