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镇咳宁(甘草次酸胆碱)是广东佛山制药厂根据国外资料拟制出来的一种新型止咳药。自1979年以来,浙江医科大学平喘药研究室为此药作了镇咳、平喘、祛痰等药理作用的研究及急性毒性试验;广东省佛山卫校药理教研组作了亚急性毒性试验,广州铁路中心医院、空军广州医院、广州市第一人民医院、南方医院、佛山市人民医院、佛山市第二人民医院、南海县人民医院等13间医院作了临床疗效观察。一、药理研究 1.镇咳作用(豚鼠镇咳实验): 方法:豚鼠32只,体重300g左右,雌雄兼用,逐个放入4L的密闭钟罩内,分别以600mmHg恒压喷入17.5％柠檬酸1分钟,记录5分钟内豚鼠咳嗽次数(咳嗽次数少于10次者弃除)。然后将豚鼠随机分为
Zhenke Ning (Glycyrrhetinic Acid Choline) is a new type of cough medicine developed by Guangdong Foshan Pharmaceutical Factory based on foreign data. Since 1979, the anti-tussive, anti-asthma, expectorant and other pharmacological effects and acute toxicity tests of this medicine have been made for the anti-asthma drug research center of Zhejiang Medical University; subacute toxicity test was conducted by the Pharmacological Teaching and Research Section of Foshan Medical College in Guangdong Province, Guangzhou. The clinical curative effect was observed in 13 hospitals, including the Central Hospital of Railway, Guangzhou Air Force Hospital, Guangzhou First People’s Hospital, Nanfang Hospital, Foshan People’s Hospital, Foshan Second People’s Hospital, and Nanhai County People’s Hospital. I. Pharmacological study 1. Antitussive effect (guinea pig antitussive test): Method: 32 guinea pigs weighing about 300g, both male and female, one by one into a closed bell 4L, respectively, with a constant pressure of 600mmHg spray 17.5% citric acid In 1 minute, record the number of coughs in the guinea pig within 5 minutes (the number of cough is less than 10 times). Then guinea pigs were randomly divided into