关于抗生素在体内动态的研究工作根盛行,这些知识,对于进行既有效而又安全的抗生素疗法有着重要意义。因此,掌握抗生素在体内动态的知识,可以说是不可缺少的。抗生素一经给药,常认为是大部分被吸收,而且随着血流在体内呈同样分布。然而,实际并非如此。例如,有的抗生素容易向尿路移行,有的抗生素则容易向胆道移行,排泄的速度也不一样。最近许多抗生素的这些体内动态上的特性被阐明了。抗生素的各种特性假如完全忽视这些知识而使用抗生素时,会造成什么样后果呢? 容易向尿路移行的抗生素,即意味着该抗生素是经过肾脏排泄的。如果对有肾功能低下的患者,长期投与具有这种特性的抗生素,当然会在体内发生蓄 The prevalence of antibiotics in vivo dynamic research work, these knowledge, for both effective and safe antibiotic therapy is of great significance. Therefore, to master the dynamic knowledge of antibiotics in the body, can be said to be indispensable. Antibiotics, once administered, are often thought to be mostly absorbed and distributed equally in the body with blood flow. However, this is not the case. For example, some antibiotics easily migrate to the urinary tract, and some antibiotics tend to migrate to the biliary tract, excretion rate is not the same. These in vivo dynamics of many antibiotics have recently been elucidated. The various characteristics of antibiotics If you completely ignore this knowledge and the use of antibiotics, what will be the result? Easy to urinary tract migration of antibiotics, which means that the antibiotics are excreted through the kidneys. If you have patients with renal dysfunction, long-term administration of antibiotics with this characteristic, of course, will occur in the body